Catalytic asymmetric total syntheses of quinine and quinidine.
نویسندگان
چکیده
The catalytic, asymmetric syntheses of quinine and quinidine were achieved in 16 steps. The recently developed salen(Al)-catalyzed enantioselective Michael addition of methyl cyanoacetate served to set the crucial C4 stereocenter in 92% ee, and a late-stage asymmetric dihydroxylation was used to differentiate the common intermediate and access the two desired diastereomeric products with high selectivity.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 126 3 شماره
صفحات -
تاریخ انتشار 2004